失调
益生元
小火焰菌属
炎症
炎症性肠病
盲肠
肠道菌群
KEAP1型
胃肠道
医学
营养基因学
免疫学
生物
疾病
内科学
基因
食品科学
生物化学
转录因子
蘑菇
作者
Ivan Stève Nguepi Tsopmejio,Miao Ding,Jiali Wei,Cong Zhao,Yu Jiang,Yuting Li,Hui Song
标识
DOI:10.1016/j.fbio.2021.101426
摘要
Flammulina velutipes and Auricularia polytricha are two popular dietary mushrooms, especially in the Northeast of China. They have revealed many pharmacological effects due to their bioactive compounds, but their possible mechanism of action involved in inflammation remains poorly known. Therefore, Inflammatory bowel disease (IBD) which is a chronic disease and progressive inflammation in the gastrointestinal tract were used to evaluate their anti-inflammatory and modulatory properties on the intestinal microbiota via the signaling pathways involved by oral administration of F. velutipes (FVE) and A. polytricha (APE). Mice were daily received 3%DSS in the drinking water followed by the daily administration of FVE and APE. The food consumption, weight variation and DAI score were assessed during the experiment and inflammatory parameters, mRNA and protein expressions to determine the possible signaling pathways involved, and the gut microbiota from the cecum by high-throughput sequencing. Data showed that APE and FVE improved clinical symptoms, inflammatory cytokines and oxidative markers. They also attenuated the mRNA and proteins expressions in colon tissue. Moreover, APE and FVE regulated DSS-induced intestinal dysbiosis and stimulated the SCFAs production. Overall, APE and FVE could improve DSS-induced IBD in mice suggesting that they represent novels therapeutic drugs and could be used as prebiotic to modulate the gut microbiota and preserve intestinal integrity.
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