生物膜
白色念珠菌
脱铁酮
化学
螯合作用
蜡螟
白色体
微生物学
毒力
生物活性
体外
生物化学
细菌
生物
有机化学
遗传学
基因
作者
Martina Bortolami,Fabiana Pandolfi,Antonella Messore,Daniele Rocco,Marta Feroci,Roberto Di Santo,Daniela De Vita,Roberta Costi,Paola Cascarino,Giovanna Simonetti,Luigi Scipione
标识
DOI:10.1016/j.bmcl.2021.128087
摘要
Candida albicans, in specific conditions, is responsible of severe invasive systemic candidiasis that are related to its ability to produce biofilm on biological and artificial surfaces. Many studies reported the role of iron in fungal growth and virulence and the ability of metal chelating agents to interfere with C. albicans metabolism, virulence and biofilm formation. Here we report the activity of 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone (deferiprone) derivatives against C. albicans planktonic cells and biofilm. Some of the studied compounds (2b and 3b) were able to chelate Fe(III) and Cu(II), and showed an interesting activity on planktonic cells (MIC50 of 32 μg/mL and 16 μg/mL respectively) and on biofilm formation (BMIC50 of 32 μg/mL and 16 μg/mL respectively) in cultured ATCC 10,231C. albicans; this activity was reduced, in a concentration dependent way, by the addition of Fe(III) and Cu(II) to the culture media. Furthermore, the most active compound 3b showed a low toxicity on Galleria mellonella larvae.
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