吲哚嗪
化学
烯丙基重排
立体选择性
铱
组合化学
催化作用
路易斯酸
取代反应
对映选择合成
选择性
有机化学
作者
Jiamin Lu,Meifang Wang,Ruigang Xu,Hongwei Sun,Xuan Zheng,Guofu Zhong,Xiaofei Zeng
标识
DOI:10.1002/ajoc.202100171
摘要
Abstract A highly efficient direct asymmetric allylic substitution (AAS) reaction of indolizine derivatives with allylic alcohols for accessing enantioenriched indolizine derivatives was realized by combining a chiral iridium complex catalyst with Lewis acid under mild reaction conditions, delivering various chiral allylation products in remarkably high yields and excellent enantioselectivities. This protocol distinguishes itself by availability of the starting materials, mild reaction conditions, broad substrate scope, high yields, excellent selectivity and easy scale‐up in a stereoselective manner, which provides a highly efficient protocol for chiral indolizines.
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