A systematic synthetic approach to phosphinophenyl-glycine and -alanine chiral phosphine ligands with amino acid moieties

Abstract ortho - and para -phosphinophenyl derivatives of glycine and alanine have been synthesised by nucleophilic phosphination of 2- and 4-fluorophenylglycine and -alanine with Ph(R)PK (R = Me, Ph). The structure of 2-diphenylphosphino-α-phenylglycine has been identified by X-ray analysis.