化学
多糖
乙酰化
微生物学
立体化学
肺炎链球菌
生物化学
基因
抗生素
生物
作者
Trevor J. Rutherford,Christopher Jones,David B. Davies,A. Elliott
标识
DOI:10.1016/0008-6215(91)84096-w
摘要
The 1H-n.m.r. spectra of the Streptococcus pneumoniae type 9V (S68 in American nomenclature) capsular polysaccharide (PS) and its O-deacetylated derivative [which is structurally identical to the S. pneumoniae type 9A (S33) PS] were assigned using COSY, relayed-COSY, and 2D-NOESY experiments. The positions of the OAc groups in the alpha-GlcA, beta-ManNAc, and alpha-Glc residues of the native 9V PS were established using 2D-n.m.r. and chemical shift arguments, and the relative proportions of different O-acetylated species were estimated by integration of well-resolved 1H-n.m.r. signals. The locations of the OAc substituents differ from those previously reported. [formula: see text].
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