结直肠癌
医学
遗传增强
恶性肿瘤
溶癌病毒
临床试验
肿瘤科
疾病
溶瘤病毒
内科学
癌症
免疫系统
前药
基因
免疫学
生物
药理学
生物化学
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2003-08-01
卷期号:3 (8): 615-622
被引量:84
摘要
Colorectal cancer (CRC) is the second most common type of malignancy in Western nations. Improvements in surgical and radiotherapeutic techniques and the increased availability of new cytotoxic drugs have improved outcome, but 50% of patients still die from recurrent or metastatic disease. Several features of its natural history render CRC a good candidate for gene therapy. Techniques include gene replacement, virus-directed enzyme-prodrug therapy, immune manipulation and virotherapy, all of which have entered clinical trials.
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