秀丽隐杆线虫
生物
RNA干扰
翻译(生物学)
基因
细胞生物学
戒毒(替代医学)
遗传学
核糖核酸
信使核糖核酸
医学
病理
替代医学
作者
J. Amaranath Govindan,Elamparithi Jayamani,Xinrui L Zhang,Peter C. Breen,Jonah Larkins-Ford,Eleftherios Mylonakis,Gary Ruvkun
摘要
Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors. Through RNAi screens in C. elegans, Ruvkun and colleagues identify signalling pathways that induce detoxification genes following disrupted translation, suggesting translational surveillance of toxins and virulence factors.
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