糖尿病
医学
入射(几何)
内科学
免疫学
乙型肝炎病毒
病毒
生理学
病毒学
内分泌学
物理
光学
作者
S. Wilberz,Hans-Joachim Partke,Frederik Dagnæs‐Hansen,L. Herberg
出处
期刊:Diabetologia
[Springer Nature]
日期:1991-01-01
卷期号:34 (1): 2-5
被引量:139
摘要
The frequency of diabetes mellitus was compared in non-obese diabetic mice before and after inadvertent exposure of the colony to mouse hepatitis virus infection. Prior to exposure, diabetes prevalence and cumulative diabetes incidence in 7-month-old mice was 65% and 25% in females and males, respectively. Diabetes incidence/quarter revealed a seasonal pattern with peaks in winter. After mouse hepatitis exposure, the diabetes incidence in the colony decreased and testing for mouse hepatitis antibody in blood samples revealed a persistent infection. In the offspring of mice delivered by caesarian section, the diabetic incidence increased sharply from a nadir of 36% to 95% and from 9% to 65% in females and males, respectively. In individual mice, diabetes resistance was strongly correlated to high titres of mouse hepatitis virus antibody. The results of this inadvertent viral infection demonstrate that a diabetes-susceptible genotype is strongly modulated by environmental factors. Investigators studying this diabetes model should strive for specific pathogen-free colony status and a high incidence of diabetes before attempting to investigate therapeutic modalities.
科研通智能强力驱动
Strongly Powered by AbleSci AI