Anti-Nomifensine Antibody Causing Immune Hemolytic Anemia and Renal Failure

An anti-Nomifensine antibody was identified in a patient with immune hemolysis and renal failure who was under Nomifensine therapy. The anti-drug specificity of the antibody was confirmed by inhibition assays using Sepharose gel-Nomifensine conjugates. Preliminary screening tests for anti-Nomifensine antibody in a population of 104 patients treated by the drug showed no further example of such immunization.