代谢组
转录组
生物
结肠炎
炎症性肠病
内科学
代谢组学
内分泌学
雄激素
睾酮(贴片)
溃疡性结肠炎
免疫学
基因表达
医学
生物化学
基因
疾病
生物信息学
激素
作者
Lei-Ning Chen,Tao Jing,Zi-Bin Lin,Wei Song,Wen-Hao Du,Xiao-Yan Fan,Chao Li,Sen Li,Xie F,Xiang‐Hong Ou,Lin Huang,Jun‐Yu Ma
标识
DOI:10.1016/j.reprotox.2022.01.005
摘要
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are widespread in developed countries and gradually increasing in developing countries. Evidences showed that man with CD has a decrease of serum testosterone, but how IBD take effects on testicular testosterone synthesis is not well elucidated. To investigate the effects of IBD on testis, we analyzed testicular metabolome and transcriptome data of the dextran sulfate sodium (DSS) induced IBD mice. As a result, metabolomic data showed that DSS indeed induced androgen decrease in mouse testis. Correspondingly, androgen synthesis associated genes, especially Lhcgr, were down-regulated in DSS testis. From the metabolomic data, we found vitamin intake associated metabolites vitamin B2 and pyridoxamine were significantly decreased, whereas fatty acid metabolism associated molecules N-lauroylglycine and N-decanoylglycine were increased in DSS testis. In addition, we found 8-hydroxy-deoxyguanosine, a DNA oxidative damage marker, and 8-oxoguanine, a molecule responsible for DNA damage repair, were also changed in DSS testis. Simultaneously, our data also showed that DSS up-regulated the expression of meiosis initiation associated gene Stra8 and oxygen transport associated genes in testis. In summary, these results depicted the complex effects of colitis on testis. These metabolites and transcripts changed in DSS testis could be used as potential targets for IBD treatment or symptom relieve.
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