SOD1
活性氧
普鲁士蓝
超氧化物歧化酶
椎间盘
氧化应激
抗氧化剂
变性(医学)
细胞生物学
细胞内
蛋白酶体
泛素
生物物理学
化学
生物化学
医学
生物
病理
解剖
基因
物理化学
电化学
电极
作者
Ting Zhou,Xiaobin Yang,Zhiqian Chen,Yangzi Yang,Xin Wang,Xiankun Cao,Chen Chen,Chunchun Han,Haijun Tian,An Qin,Jingke Fu,Jie Zhao
标识
DOI:10.1002/advs.202105466
摘要
Abstract Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice. This technology mainly increases the reactive oxygen species (ROS) in the IVD. As so, it is particularly critical to develop strategies to avoid this degeneration mechanism. Prussian blue nanoparticles (PBNPs) are found to enhance development under magnetic resonance T1 and have antioxidant enzyme activity. The key results of the present study confirm that PBNPs alleviate intracellular oxidative stress and increase the intracellular activities of antioxidant enzymes, such as superoxide dismutase 1 (SOD1). PBNPs can rescue nucleus pulposus cell degeneration by increasing oxidoreductase system‐related mRNA and proteins, especially by stabilizing SOD1 from ubiquitination‐proteasome degradation, thus improving the mitochondrial structure to increase antioxidation ability, and finally rescuing ROS‐induced IVDD in a rat model. Therefore, it is considered that PBNPs can be a potential antioxidation‐protective discography contrast agent.
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