An Adenine‐Based Biological Metal‐Organic Framework as an Efficient Luminescent Sensor for Tetracycline Detection

Because of their misuse and poor management, antibiotics pose a significant threat to the ecological environment and human health. The development of highly sensitive and effective sensors to detect such environmental contaminants is a crucial and challenging task. As a new class of desirable biocompatible materials, biological metal–organic frameworks are considered as a viable platform for sensing applications. Herein, we report the synthesis of biological luminescent metal–organic framework [Zn 6 Ad 4 (BPDC-(OH) 2 ) 4 ] n ( JNU-104 ) using adenine (Ad) and 2,2′-dihydroxy-1,1′-biphenyl-4,4′-dicarboxylic acid [BPDC-(OH) 2 ] as organic linkers. JNU-104 serves as a robust and sensitive luminescent sensor for detecting tetracycline antibiotics in aqueous media with low limits of detection (LODs) of 0.023, 0.029 and 0.024 μM for tetracycline (TC), oxytetracycline (OTC), and chlortetracycline (CTC), respectively. Furthermore, the MOF-based test strips show a rapid and visualizable luminescent response to tetracycline antibiotics, making JNU-104 a promising candidate for practical applications in sensing.