高胰岛素血症
内科学
内分泌学
胰岛素抵抗
细胞毒性T细胞
CD8型
胰岛素受体
生物
胰岛素
背景(考古学)
T细胞
免疫学
作者
Inga Kavazović,Mia Krapić,Ammarina Beumer-Chuwonpad,Bojan Polić,Tamara Turk Wensveen,Niels A. Lemmermann,Klaas P.J.M. van Gisbergen,Felix M. Wensveen
出处
期刊:Diabetes
[American Diabetes Association]
日期:2022-01-14
卷期号:71 (4): 706-721
被引量:1
摘要
Type 2 diabetes (T2D) causes an increased risk of morbidity and mortality in response to viral infection. T2D is characterized by hyperglycemia and is typically associated with insulin resistance and compensatory hyperinsulinemia. CD8 T cells express the insulin receptor, and previously, we have shown that insulin is able to directly modulate effector CD8 T-cell function. We therefore hypothesized that memory CD8 T-cell responsiveness in the context of T2D is negatively impacted by hyperinsulinemia or hyperglycemia. Using a mouse model for T2D, we could show that memory CD8 T-cell function was significantly reduced in response to rechallenge by viral infection or with melanoma cells. Basal insulin injection of mice increased GLUT-1 expression and glucose uptake in memory CD8 T-cell precursors early after infection, which was prevented when these cells were deficient for the insulin receptor. However, neither insulin injection nor insulin receptor deficiency resulted in a difference in metabolism, memory formation, cytokine production, or recall responses of memory CD8 T cells compared with controls. Importantly, in context of obesity, insulin receptor deficiency on CD8 T cells did not affect the functional capacity of memory CD8 T cells. In contrast, we could show in vitro and in vivo that hyperglycemia significantly impairs the antiviral capacity of memory CD8 T cells. Our findings indicate that obesity impairs the memory CD8 T-cell response against viral infection and cancer through the detrimental effects of hyperglycemia rather than hyperinsulinemia.
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