HMGB1
愤怒(情绪)
糖尿病
痴呆
胰岛素抵抗
糖基化
医学
胰岛素受体
血脑屏障
神经科学
生物信息学
神经退行性变
受体
内科学
内分泌学
生物
疾病
中枢神经系统
作者
Jae-Ho Jeong,Dong Hoon Lee,Jeong Sup Song
标识
DOI:10.1016/j.biopha.2022.112933
摘要
Diabetes contributes to the onset of various diseases, including cancer and cardiovascular and neurodegenerative diseases. Recent studies have highlighted the similarities and relationship between diabetes and dementia as an important issue for treating diabetes-related cognitive deficits. Diabetes-related dementia exhibits several features, including blood-brain barrier disruption, brain insulin resistance, and Aβ over-accumulation. High-mobility group box1 (HMGB1) is a protein known to regulate gene transcription and cellular mechanisms by binding to DNA or chromatin via receptor for advanced glycation end-products (RAGE) and toll-like receptor 4 (TLR4). Recent studies have demonstrated that the interplay between HMGB1, RAGE, and TLR4 can impact both neuropathology and diabetic alterations. Herein, we review the recent research regarding the roles of HMGB1-RAGE-TLR4 axis in diabetes-related dementia from several perspectives and emphasize the importance of the influence of HMGB1 in diabetes-related dementia.
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