糖尿病性视网膜病变
丝氨酸
精氨酸
血管通透性
蛋白激酶C
视网膜
糖尿病性黄斑水肿
蛋白激酶A
医学
眼科
激酶
化学
药理学
磷酸化
内科学
内分泌学
糖尿病
生物化学
氨基酸
作者
Naseeb K. Malhi,Claire S. Allen,Elizabeth A. Stewart,Katherine C. Horton,Federica Riu,Jennifer Batson,Winfried M Amoaku,Jonathan M. Morris,Kenton P. Arkill,David W. Bates
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2022-06-01
卷期号:322 (6): H1014-H1027
被引量:3
标识
DOI:10.1152/ajpheart.00001.2022
摘要
VEGF-A165a splicing is induced by hyperglycemia through PKC-mediated activation of SRPK1 in RPE cells, increasing their permeability and angiogenic capability. SRPK1 inhibitors can be given as eye drops to reduce retinal permeability and edema in diabetic retinopathy.
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