化学
DNA
基质(水族馆)
组合化学
共轭体系
范围(计算机科学)
药物发现
化学生物学
纳米技术
计算生物学
生物化学
有机化学
计算机科学
生物
材料科学
聚合物
生态学
程序设计语言
作者
Xianfu Fang,Yiting Wang,Pengyang He,Huilin Liao,Gong Zhang,Yangfeng Li,Yizhou Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-04-25
卷期号:24 (17): 3291-3296
被引量:20
标识
DOI:10.1021/acs.orglett.2c01187
摘要
Benzoheterocyclics have been widely adopted as drug-like core scaffolds that can be incorporated into DNA-encoded chemical library technology for high-throughput hit discovery. Here, we present a visible light-promoted divergent synthesis of on-DNA benzoheterocycles from aldehydes. Four types of DNA-conjugated benzoheterocyclics were obtained under mild conditions with a broad substrate scope. A cross substrate scope study, together with enzymatic ligation and subsequent chemical diversifications, were conducted, demonstrating the feasibility of this approach in DNA-encoded chemical library construction.
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