病理生理学
去神经支配
高血压的病理生理学
心脏病学
医学
内科学
交感神经系统
血压
交感神经失神经
作者
Murray Esler,John W. Osborn,Markus P. Schlaich
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2024-04-01
标识
DOI:10.1161/hypertensionaha.123.21715
摘要
The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20 th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and transmitter release allowed demonstration of the importance of neural mechanisms in the initiation and maintenance of the arterial blood pressure elevation in hypertension. This led to the development of a device treatment of hypertension, catheter-based renal denervation, which we will discuss.
科研通智能强力驱动
Strongly Powered by AbleSci AI