自愈水凝胶
巨噬细胞极化
巨噬细胞
伤口愈合
免疫系统
细胞生物学
材料科学
生物材料
纳米技术
M2巨噬细胞
体外
化学
生物
免疫学
生物化学
高分子化学
作者
Pravin Shankar Giri,Subha Narayan Rath
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-03-27
卷期号:7 (4): 2413-2422
标识
DOI:10.1021/acsabm.4c00066
摘要
The interaction between biomaterials and the immune system plays a pivotal role in determining the success or failure of implantable devices. Macrophages, as key orchestrators of immune responses, exhibit diverse reactions that influence tissue integration or lead to implant failure. This study focuses on unraveling the intricate relationship between macrophage phenotypes and biomaterials, specifically hydrogels, by employing THP-1 cells as a model. Through a comprehensive investigation using polysaccharide, polymer, and protein-based hydrogels, our research sheds light on how the properties of hydrogels influence macrophage polarization. Phenotypic observations, biochemical assays, surface marker expression, and gene expression profiles collectively demonstrate the differential macrophage polarization abilities of polysaccharide-, polymer-, and protein-based hydrogels. Moreover, our indirect coculture studies reveal that hydrogels fostering M2 polarization exhibit exceptional wound-healing capabilities. These findings highlight the crucial role of the hydrogel microenvironment in adjusting macrophage polarization, offering a fresh avenue for refining biomaterials to bolster advantageous immune responses and improve tissue integration. This research contributes valuable insights for designing biomaterials with tailored properties that can guide macrophage behavior, ultimately improving the overall success of implantable devices.
科研通智能强力驱动
Strongly Powered by AbleSci AI