PI3K/AKT/mTOR通路
PTEN公司
胰腺癌
癌症研究
基因亚型
信号转导
胞饮病
自噬
化学
mTOR抑制剂的发现与发展
癌症
二硫键
细胞生物学
作者
Rachel A. Burge,Lucas Bialousow,Amanda J. Linke,Hannah S. Coalson,Sara J. Adair,Kamala Sundararaj,Merissa Smith,Cameron Bumbleburg,Todd W. Bauer,David F. Kashatus,G. Aaron Hobbs
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-10-24
卷期号:: OF1-OF14
被引量:1
标识
DOI:10.1158/0008-5472.can-24-4501
摘要
PTEN inactivation by intramolecular disulfide bond formation and elevated expression of PI3K isoforms in pancreatic cancer leads to unchecked KRAS-independent PI3K signaling, highlighting the need for therapeutic approaches targeting constitutive PI3K signaling.
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