2025 American College of Rheumatology ( ACR ) Guideline for the Treatment of Systemic Lupus Erythematosus

This guideline presents direction regarding treatment and management of SLE and provides a foundation for well-informed, shared clinician-patient decision-making. These recommendations should not be used to limit or deny access to therapies, as treatment decisions may vary due to the unique clinical situation and personal preferences of each person with SLE.