Trauma Induced Acute Redox Imbalance, the Filling Oxidant Sinks, and a Plausible Food as Medicine Solution

Trauma is a leading cause of death worldwide. While early deaths are most commonly from hemorrhage and direct organ injuries, delayed deaths are mostly caused by the fallout of inflammation, presumably induced by oxidative stress. Increasing evidence shows that many or most of the complications of trauma are also associated with oxidative stress. In this manuscript we review the current literature on trauma associated redox imbalance, bridging the gap between basic science research and clinical practice from a broad perspective. The triple oxidant sink metaphor is presented to give a visual gauge of how redox balance might be achieved. We then introduce a plausible multimodal redox balancing regimen, using food as medicine.