化学
磺酰
芳基
烷基
二氢吡啶
药物化学
催化作用
有机化学
钙
作者
Soe L. Tun,Grant N. Shivers,F. Christopher Pigge
标识
DOI:10.1021/acs.joc.3c00017
摘要
4-Picoline derivatives are converted to the corresponding aryl picolyl sulfones upon treatment with aryl sulfonyl chlorides and Et3N in the presence of catalytic DMAP. The reaction proceeds smoothly for a variety of alkyl and aryl picolines using a range of aryl sulfonyl chlorides. The reaction is believed to involve N-sulfonyl 4-alkylidene dihydropyridine intermediates and results in formal sulfonylation of unactivated picolyl C-H bonds.
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