化学
羰基化
钯
天然产物
全合成
催化作用
组合化学
一氧化碳
有机化学
生化工程
工程类
作者
Hunter Sims,Mingji Dai
标识
DOI:10.1021/acs.joc.2c02746
摘要
Carbon monoxide is a cheap and abundant C1 building block that can be readily incorporated into organic molecules to rapidly build structural complexity. In this Perspective, we outline several recent (since 2015) examples of palladium-catalyzed carbonylations in streamlining complex natural product total synthesis and highlight the strategic importance of these carbonylation reactions in the corresponding synthesis. The selected examples include spinosyn A, callyspongiolide, perseanol, schizozygane alkaloids, cephanolides, and bisdehydroneostemoninine and related stemona alkaloids. We also provide our perspective about the recent advancements and future developments of palladium-catalyzed carbonylations.
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