粘液
纳米载体
化学
纳米颗粒
聚合物
渗透(战争)
生物物理学
纳米材料
生物污染
等电点
粘蛋白
化学工程
纳米技术
材料科学
有机化学
生物化学
膜
生态学
运筹学
工程类
生物
酶
作者
Yubin Ma,Yiyang Guo,Shan Liu,Yunbin Hu,Cheng Yang,Gang Cheng,Changying Xue,Yi Y. Zuo,Bingbing Sun
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-07-26
卷期号:23 (16): 7552-7560
被引量:4
标识
DOI:10.1021/acs.nanolett.3c02128
摘要
Zwitterionic polymers have emerged as promising trans-mucus nanocarriers due to their superior antifouling properties. However, for pH-sensitive zwitterionic polymers, the effect of the pH microenvironment on their trans-mucus fate remains unclear. In this work, we prepared a library of zwitterionic polydopamine-modified silica nanoparticles (SiNPs-PDA) with an isoelectric point of 5.6. Multiple-particle tracking showed that diffusion of SiNPs-PDA in mucus with a pH value of 5.6 was 3 times faster than that in mucus with pH value 3.0 or 7.0. Biophysical analysis found that the trans-mucus behavior of SiNPs-PDA was mediated by hydrophobic and electrostatic interactions and hydrogen bonding between mucin and the particles. Furthermore, the particle distribution in the stomach, intestine, and lung demonstrated the pH-mediated mucus penetration behavior of the SiNPs-PDA. This study reveals the pH-mediated mucus penetration behavior of zwitterionic nanomaterials, which provides rational design strategies for zwitterionic polymers as nanocarriers in various mucus microenvironments.
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