医学
睾酮(贴片)
雌激素
性二态性
免疫系统
内科学
激素
雄激素
动静脉瘘
生物
内分泌学
性激素结合球蛋白
性激素受体
性类固醇
生理学
雌激素受体
外科
免疫学
类固醇
癌症
乳腺癌
作者
Keyuree Satam,Yuichi Ohashi,Carly Thaxton,Luis Gonzalez,Ocean Setia,Hualong Bai,Yukihiko Aoyagi,Yangzhouyun Xie,Weichang Zhang,Bogdan Yatsula,Kathleen A. Martin,Yujun Cai,Alan Dardik
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2023-07-01
卷期号:325 (1): H77-H88
被引量:2
标识
DOI:10.1152/ajpheart.00049.2023
摘要
After arteriovenous fistula creation, females have lower rates of maturation and higher rates of failure than males. In a mouse model of venous adaptation that recapitulates human fistula maturation, sex hormones may be mechanisms of the sexual dimorphism: testosterone is associated with reduced shear stress, whereas estrogen is associated with increased immune cell recruitment. Modulating sex hormones or downstream effectors suggests sex-specific therapies and could address disparities in sex differences in clinical outcomes.
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