类有机物
高含量筛选
药物开发
药物发现
药品
计算生物学
神经科学
计算机科学
医学
精密医学
生物信息学
生物
病理
药理学
细胞
遗传学
作者
Jin-Qi Zhou,Ling‐Hui Zeng,Chen-Tao Li,Da-Hong He,Hao-Duo Zhao,Yanchao Xu,Zi-Tian Jin,Chong Gao
标识
DOI:10.4103/1673-5374.367983
摘要
At the level of in vitro drug screening, the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening. There are few systematic reports on brain organoids, as a new three-dimensional in vitro model, in terms of model stability, key phenotypic fingerprint, and drug screening schemes, and particularly regarding the development of screening strategies for massive numbers of traditional Chinese medicine monomers. This paper reviews the development of brain organoids and the advantages of brain organoids over induced neurons or cells in simulated diseases. The paper also highlights the prospects from model stability, induction criteria of brain organoids, and the screening schemes of brain organoids based on the characteristics of brain organoids and the application and development of a high-content screening system.
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