Statin use is associated with reduced risk of incident intracerebral hemorrhage: A prospective population-based cohort study

BACKGROUND: The association between statin use and the risk of incident intracerebral hemorrhage (ICH) remains controversial, with concerns about a potential increased risk of ICH among statin users. AIMS: This study aimed to investigate the association between statin use and incident ICH in the general population. METHODS: This prospective cohort study utilized data from UK Biobank. Cox proportional regression models were employed to estimate hazard ratios (HRs) for the association between statin use and incident ICH in both unmatched and propensity score-matched (PSM) cohorts, adjusting for sociodemographic characteristics, lifestyle factors, comorbidities, and concurrent medication use. RESULTS: for interaction = 0.025 and 0.062, respectively, in the PSM cohort) in relation to ICH risk. CONCLUSION: In this large population-based study, statin use was associated with a reduced risk of incident ICH, providing further evidence for the long-term safety of statin therapy with respect to ICH risk in the general population and across diverse subgroups.Data access statement:UK Biobank database is available on application by approved researchers.