Disinfection By‐Products in Aquaculture: Sources, Impacts, Removal and Future Research

ABSTRACT Aquaculture disinfection processes are critical for biosecurity, especially with the rapid development of intensive aquaculture, yet they also yield disinfection by‐products (DBPs) with significant and underexplored impacts on aquatic organisms and humans. This review provides the first comprehensive evaluation of DBPs in aquaculture, focusing on their sources, environmental and health impacts, removal strategies, and future research directions. It provides a deep analysis of DBP sources, including disinfectants, organic precursors, additives like antibiotics and hormones, and their transformation pathways in aquaculture environments. The review further assesses the ecological and physiological effects of DBPs on aquatic species, along with the human health risks posed by DBP bioaccumulation. Current DBP removal strategies are evaluated, highlighting technological gaps and advocating for advanced, aquaculture‐specific solutions, such as enhanced filtration, biofiltration, and low‐DBP disinfection methods. Despite evidence of their harmful effects on fish health, ecosystem stability, and potential human exposure, DBPs in aquaculture lack adequate risk assessments and regulatory frameworks. This review underscores the urgent need for robust monitoring systems, targeted toxicity research, and a cohesive regulatory structure to manage DBPs, thereby advancing sustainable aquaculture practices that safeguard environmental and public health.