废止
对映选择合成
化学
催化作用
铜
组合化学
形式综合
分子
有机化学
作者
Ze‐Shu Wang,Hao-Jin Xu,Yang‐Bo Chen,Long‐Wu Ye,Bo Zhang,Peng‐Cheng Qian
摘要
The enantioselective transformation of easily accessible 1,2-diketones represents a quick pathway towards enantioenriched molecules. Herein, we disclose a copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations, enabling the efficient and atom-economical construction of axially chiral arylpyrroles bearing 1,3-dioxole moieties with good to excellent enantioselectivities under mild reaction conditions. Importantly, this methodology constitutes the first enantioselective formal [4+1] annulation of 1,2-diketones.
科研通智能强力驱动
Strongly Powered by AbleSci AI