医学
病理生理学
急性播散性脑脊髓炎
脑炎
神经炎症
脑病
2019年冠状病毒病(COVID-19)
鉴别诊断
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
多发性硬化
脑脊髓炎
重症监护医学
神经退行性变
冲程(发动机)
格林-巴利综合征
疾病
免疫学
儿科
病理
内科学
病毒
传染病(医学专业)
机械工程
工程类
作者
Ruth Nicole Brown,Laura Benjamin,Michael P Lunn,Tehmina Bharucha,Michael S Zandi,Chandrashekar Hoskote,Patricia McNamara,Hadi Manji
标识
DOI:10.1136/bmj-2022-073923
摘要
Abstract Although neurological complications of SARS-CoV-2 infection are relatively rare, their potential long term morbidity and mortality have a significant impact, given the large numbers of infected patients. Covid-19 is now in the differential diagnosis of a number of common neurological syndromes including encephalopathy, encephalitis, acute demyelinating encephalomyelitis, stroke, and Guillain-Barré syndrome. Physicians should be aware of the pathophysiology underlying these presentations to diagnose and treat patients rapidly and appropriately. Although good evidence has been found for neurovirulence, the neuroinvasive and neurotropic potential of SARS-CoV-2 is limited. The pathophysiology of most complications is immune mediated and vascular, or both. A significant proportion of patients have developed long covid, which can include neuropsychiatric presentations. The mechanisms of long covid remain unclear. The longer term consequences of infection with covid-19 on the brain, particularly in terms of neurodegeneration, will only become apparent with time and long term follow-up.
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