Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project

医学 肾脏疾病 肾病科 精密医学 背景(考古学) 急性肾损伤 内科学 肾功能 疾病 内型 生物信息学 重症监护医学 病理 生物 古生物学
作者
Tarek M. El‐Achkar,Michael T. Eadon,Matthias Kretzler,Jonathan Himmelfarb,Blue B. Lake,Kun Zhang,Stewart H. Lecker,Alexander Morales,Steve Bogen,Afolarin Amodu,Laurence Beck,Joel Henderson,Titlayo Ilori,Shana Maikhor,Ingrid Onul,Insa M. Schmidt,Ashish Verma,Sushrut S. Waikar,Pranav Yadati,Guanghao Yu,Mia R. Colona,Gearoid M. McMahon,Nir Hacohen,Anna Greka,Paul Hoover,Jamie L. Marshall,Mark P. Aulisio,William S. Bush,Yijiang Chen,Dana C. Crawford,Anant Madabhushi,Vidya Sankar Viswanathan,Lakeshia Bush,Leslie Cooperman,Larry A. Greenbaum,Leal Herlitz,Stacey E. Jolly,Jane Nguyen,Charles M. O’Malley,John O’Toole,Ellen L. Palmer,Emilio D. Poggio,Kassandra Spates-Harden,John R. Sedor,Dianna Sendrey,Jonathan J. Taliercio,Paul S. Appelbaum,Olivia Balderes,Jonathan Barasch,Cecilia Berroue,Andrew S. Bomback,Pietro A. Canetta,Vivette D. D’Agati,Krzysztof Kiryluk,Vivette D. D’Agati,Karla Mehl,Maya Sabatello,Ning Shang,Joana P. Gonçalves,Roy Lardenoije,Lukasz G. Migas,Raf Van de Plas,Helmut G. Rennke,Evren U. Azeloglu,Kirk N. Campbell,Steven G. Coca,Cijang He,John Cijiang He,Srinivas Ravi Iyengar,Seanee Lefferts,Girish N. Nadkarni,Michele Patel,Joji Tokita,Stephen A. Ward,Yuguang Xiong,Abraham Verdoes,Angela R. Sabo,Daria Barwinska,Debora L. Gisch,James C. Williams,Katherine J. Kelly,Kenneth W. Dunn,Mahla Asghari,Michael T. Eadon,Michael J. Ferkowicz,Pierre C. Dagher,Ricardo Melo Ferreira,Seth Winfree,Sharon B. Bledsoe,Stephanie Wofford,Tarek M. El‐Achkar,Timothy A. Sutton,William S. Bowen,Ying‐Hua Cheng,Austen Slade,Elizabeth Record,Ying‐Hua Cheng,Katy Börner,Bruce Herr,Yashvardhan Jain,Ellen M. Quardokus,Mohamed G. Atta,Lauren Bernard,Steven Menez,Chirag R. Parikh,Celia P. Corona‐Villalobos,Ashley Wang,Yumeng Wen,Alan Xu,Sarah Chen,Isabel Donohoe,Camille Johansen,Sylvia E. Rosas,Jennifer K. Sun,Joseph Ardayfio,Jack Bebiak,Taneisha Campbell,Monica Fox,Ifeoma Ulasi,Robert Koewler,Roy Pinkeney,John Saul,Anna Shpigel,Pottumarthi Prasad,Sethu M. Madhavan,Samir M. Parikh,Brad H. Rovin,John P. Shapiro,Christopher Anderton,Jessica Lukowski,Ljiljana Paša‐Tolić,Dušan Veličković,George Oliver,Weiguang Mao,Rachel Sealfon,Olga G. Troyanskaya,Ari H. Pollack,Yury Goltsev,Brandon Ginley,Kun Zhang,Kavya Anjani,Zoltán Lászik,Tariq Mukatash,Garry P. Nolan,David H. Beyda,Erika Bracamonte,Frank C. Brosius,Baltazar Campos,Nicole Marquez,Katherine Mendoza,Raymond Scott,Bijin Thajudeen,Rebecca Tsosie,Gregory Woodhead,Milda R. Saunders,Rita R. Alloway,Paul J. Lee,Adele Rike,Tiffany Shi,E. Steve Woodle,Petter Bjornstad,Elena W.Y. Hsieh,Jessica Kendrick,Laura Pyle,Joshua M. Thurman,Carissa Vinovskis,Julia Wrobel,Nicholas Lucarelli,Pinaki Sarder,James T. Bui,Eunice Carmona-Powell Ron Gaba,Tanika N. Kelly,Michelle J. Pena,Natalie Meza,D. Eugene Redmond,Amada Renteria,Ana C. Ricardo,Suman Setty,Anand K. Srivastava,Fadhl Alakwaa,Heather Ascani,Ul Balis,Markus Bitzer,Victoria M. Blanc,Nikki Bonevich,Ninive C. Conser,Dawit Demeke,Rachel Dull,Sean Eddy,Renee Frey,John R. Hartman,Yongqun He,Jeffrey B. Hodgin,Matthias Kretzler,Chrysta Lienczewski,Jinghui Luo,Fadhl Alakwaa,Phillip J. McCown,Rajasree Menon,Viji Nair,Edgar A. Otto,Rebecca Reamy,Michael Rose,Jennifer A. Schaub,Becky Steck,Zachary Wright,Alyson Coleman,Dorisann Henderson-Brown Jerica Berge,Maria Luiza Caramori,Oyedele Adeyi,Patrick H. Nachman,Sami Safadi,Siobhan Flanagan,Sisi Ma,Susan Klett,Susan M. Wolf,Tasma Harindhanavudhi,Via Rao,Peter R. Bream,Anne Froment,Scott D. Kelley,Amy K. Mottl,Evan Zeitler,Filitsa Bender,Michele Elder,Matthew Gilliam,Daniel E. Hall,John A. Kellum,Raghavan Murugan,Paul M. Palevsky,Matthew R. Rosengart,Roderick J. Tan,Mitchell Tublin,James Winters,Shweta Bansal,Richard Montellano,Annapurna Pamreddy,Kumar Sharma,Manjeri A. Venkatachalam,Hongping Ye,Guanshi Zhang,Mujeeb Basit,Qi Cai,Allen R. Hendricks,S. Susan Hedayati,Asra Kermani,Simon J. Craddock Lee,Shihong Ma,R. Tyler Miller,Orson W. Moe,Harold S. Park,Jiten Patel,Anil K. Pillai,Kamalanathan K. Sambandam,José Torrealba,Robert D. Toto,Tanima Arora,Nancy Wang,Natasha Wen,Dianbo Zhang,Charles E. Alpers,Ashley Berglund,Brooke Berry,Kristina N. Blank,Keith Brown,Jonas Carson,Daniel J. Weiner,Ian H. de Boer,Ashveena Dighe,Frederick Dowd,Stephanie M. Grewenow,Jonathan Himmelfarb,Andrew N. Hoofnagle,Nichole Jefferson,Brandon Larson,Christine P. Limonte,Emilio D. Poggio,Sean D. Mooney,Yunbi Nam,Chris Park,Jimmy Phuong,Kasra A. Rezaei,Glenda V. Roberts,Natalya Sarkisova,Stuart J. Shankland,Jaime Snyder,Christy Stutzke,Katherine R. Tuttle,Artit Wangperawong,Adam B. Wilcox,Kayleen Williams,Bessie A. Young,Jamie Allen,Richard M. Caprioli,Mark de Caestecker,Katerina V. Djambazova,Martin Dufresne,Melissa A. Farrow,Agnes B. Fogo,Kavya Sharman,Jeffrey M. Spraggins,Jeannine Basta,Kevin M. Conlon,Sabine M. Diettman,Joseph P. Gaut,Madhurima Kaushal,Sanjay Jain,Amanda Knoten,Brittany Minor,Gerald Nwanne,Anitha Vijayan,Bo Zhang,Tanima Arora,Lloyd G. Cantley,Angela M. Victoria Castro,Vijayakumar R. Kakade,Gilbert Moeckel,Dennis G. Moledina,Melissa Shaw,F. Perry Wilson
出处
期刊:American Journal of Kidney Diseases [Elsevier]
卷期号:83 (3): 402-410 被引量:4
标识
DOI:10.1053/j.ajkd.2023.08.015
摘要

Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes defined clinically by serial measures of kidney function. Each condition possesses strong histopathologic associations, including glomerular obsolescence or acute tubular necrosis, respectively. Despite such characterization, there remains wide variation in patient outcomes and treatment responses. Precision medicine efforts, as exemplified by the Kidney Precision Medicine Project (KPMP), have begun to establish evolving, spatially anchored, cellular and molecular atlases of the cell types, states, and niches of the kidney in health and disease. The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples. This perspective outlines the structure of the KPMP, its approach to the integration of these diverse datasets, and its major outputs relevant to future patient care.
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