False positivity for PLA2R1 antibody measured by ELISA in a nephrotic patient with no membranous nephropathy

False-positive anti-PLA2R ELISA testing in patients with diabetes mellitusKidney InternationalVol. 103Issue 2PreviewWe found the study by Hoxha et al., "False Positivity for PLA2R1 Antibody Measured by ELISA in a Nephrotic Patient With No Membranous Nephropathy," to be of interest.1 We identified 2 similar patients with biopsy-proven diabetic nephropathy with false-positive phospholipase A2 receptor (PLA2R) testing by enzyme-linked immunosorbent assay (ELISA; patients 1 and 2 in Table 1). Within a 5-year period, we had 6 of 5058 serology cases that were PLA2R-positive by ELISA and negative by indirect immunofluorescence assay (0.12%). Full-Text PDF