乌头
毛茛科
化学
立体化学
生物碱
IC50型
二维核磁共振波谱
生物化学
生物
体外
植物
作者
Yinlin Zhou,Duan-Na Zhang,Ji-Xu Qiao,Jing Wu,Yong-Ming Yan,Zhixing Cao,Cheng Peng,Yuzhu Tan
出处
期刊:Phytochemistry
[Elsevier]
日期:2023-03-01
卷期号:207: 113558-113558
被引量:3
标识
DOI:10.1016/j.phytochem.2022.113558
摘要
Six undescribed alkaloids together with 15 known alkaloids were isolated from the aerial parts of Aconitum carmichaelii. Their structures were elucidated extensively by NMR and HRESIMS spectroscopy. The absolute configurations of N-formyllaurotetanine, and the known compounds glaucine-β-N-oxide and glaucine-α-N-oxide were established by electronic circular dichroism (ECD) spectra. Notably, it was the discovery of rare indole alkaloids from the genus Aconitum, and biosynthetic pathway of compounds 1 and 6 was deduced. Evaluation of the antiproliferative activity of these alkaloids demonstrated that costemline exhibited significant anti-proliferation effects against HCT116, SKOV3, and A549 cells with IC50 values of 5.6, 14.2, and 6.8 μM, respectively. Costemline could also inhibit the cell invasion activity of HCT116 cells. Mechanistic studies in HCT116 cells suggested that the antiproliferative activity of costemline was attributable to SIRT1/ROCK1/P-STAT3 pathways regulation. This study revealed the potential for developing and utilizing the aerial parts of Aconitum carmichaelii.
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