A guanidiniocarbonyl-pyrrole functionalized cucurbit[7]uril derivative as a cytomembrane disruptor for synergistic antibacterial therapy

. Significantly, due to the strong binding between GCP and the bacterial membrane, GCPCB can effectively eradicate the bacteria encapsulated within. Furthermore, the formation of a host-guest complex between GCPCB and berberine hydrochloride (BH) not only enhances synergistic destructive activity against both species of bacteria but also provides a potential supramolecular platform for effective bacterial membrane destruction.