试验药物
医学
宫颈癌
疾病
癌症
放射治疗
表观遗传学
PI3K/AKT/mTOR通路
肿瘤科
血管内皮生长因子
生物信息学
重症监护医学
内科学
临床试验
血管内皮生长因子受体
生物
信号转导
基因
生物化学
作者
Rakesh Kore,Ekta Shirbhate,Vaibhav Singh,Achal Mishra,Ravichandran Veerasamy,Harish Rajak
标识
DOI:10.1080/07357907.2024.2373841
摘要
Currently, cervical cancer (CC) is the fourth recorded widespread cancer among women globally. There are still many cases of metastatic or recurring disease discovered, despite the incidence and fatality rates declining due to screening identification and innovative treatment approaches. Palliative chemotherapy continues to be the standard of care for patients who are not contenders for curative therapies like surgery and radiotherapy. This article seeks to provide a thorough and current summary of therapies that have been looked into for the management of CC. The authors emphasize the ongoing trials while reviewing the findings of clinical research. Agents that use biological mechanisms to target different molecular pathways such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR), poly ADP-ribosepolymerase (PARP), and epigenetic biological mechanisms epitomize and offer intriguing research prospects.
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