RADIOLOGIC AND PATHOLOGIC ANALYSIS OF SOLITARY BONE LESIONS

The mineralized matrix patterns demonstrated in clinical radiographs of primary bone neoplasms and related disorders help to predict matrices, and have diagnostic significance. These radiographic patterns may yield important clues as to the true nature of a lesion, especially when only limited biopsy material is available from extraosseous or nonrepresentative areas. Therefore, in the evaluation of bone tumors and tumor-like conditions, it is of extreme importance to correlate the histologic findings with the radiographic examination and to know precisely the location at which the biopsy material was obtained. Patterns of mineralization may be the only remnants of a pre-existing lesion that has undergone sarcomatous transformation, such as in bone infarcts, enchondromas, or osteochondromas. The pre-eminent item of importance for patient care is the diagnosis of a malignant process. However, failure to appreciate antecedent benign conditions will not contribute toward a better understanding of tumor biology or a determination of those benign lesions that warrant removal or close clinical follow-up. Integration of matrix data with knowledge of the anatomic location of a lesion, the character of its margins, and the periosteal reaction patterns it produces permits prognostication and often, specific diagnosis.