化学
类型(生物学)
立体化学
计算生物学
生物
生态学
作者
Youzhe Chen,Hong-Bo Jin,Weiliang Xiong,Zhuangjie Fang,Wenping Sun,Yiguang Zhu,Changsheng Zhang,Yonghui Zhang,Wenjun Zhang,Changsheng Zhang
标识
DOI:10.1021/acs.orglett.4c00168
摘要
A known polycyclic tetramate macrolactam (aburatubolactam C, 3) and three new ones (aburatubolactams D–F, 4–6, respectively) were isolated from the marine-derived Streptomyces sp. SCSIO 40070. The absolute configuration of 3 was established by X-ray analysis. A combinatorial biosynthetic approach unveiled biosynthetic enzymes dictating the formation of distinct 5/5-type ring systems (such as C7–C14 cyclization by AtlB1 in 5 and C6–C13 cyclization by AtlB2 in 6) in aburatubolactams.
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