Joint association of heavy metals and polycyclic aromatic hydrocarbons exposure with depression in adults

Heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) represent significant components of environmental pollution, typically occurring as mixtures, raising concerns about their potential impact on human health. However, the combined effect of HMs and PAHs exposure on depression has not been explored. Leveraging National Health and Nutrition Examination Survey (NHANES) data spanning 2005 to 2016, we employ survey-weighted multiple logistic regression models to probe the interrelation between HMs, PAHs, and depression. This exploration is complemented by age and gender-stratified analyses, as well as a determination of the dose-response linkage via restricted cubic spline regression. Furthermore, the combined impact of HMs and PAHs on depression was evaluated through a range of statistical methodologies. The study encompasses 7732 adults. Our findings unveil notable associations, indicating the significant influence of cadmium (Cd), lead (Pb), and all six PAHs metabolites on depression. Moreover, mixed exposure to HMs and PAHs emerges as a substantial contributor to an augmented depression risk, with Cd, Pb, 1-hydroxynaphthalene (1-NAP), 2-hydroxyfluorene (2-FLU), and 1-hydroxypyrene (1-PYR) likely driving this positive relationship. Intriguingly, subgroup analyses highlight greater prominence of these connections among individuals aged 20–59 and among women. Furthermore, the results tentatively suggest a potential interplay between Cd and 2-NAP in relation to depression. This study posits that exposure to both individual and combined HMs and PAHs may be associated with an elevated risk of depression. Further prospective investigations are warranted to substantiate these findings.