生物膜
材料科学
聚乳酸
生物相容性材料
骨整合
脚手架
生物医学工程
纳米技术
表面改性
植入
化学工程
复合材料
聚合物
工程类
外科
生物
细菌
医学
遗传学
作者
Xiaokang Na,Huilong Liu,Xuyuan Li,Ming Du,Tao Wang,Zunmin Zhang,Chao Wu
出处
期刊:Nano Today
[Elsevier]
日期:2024-02-01
卷期号:54: 102086-102086
标识
DOI:10.1016/j.nantod.2023.102086
摘要
The increasing aging population has created a huge demand for osteogenic implants. In this study, we report a biogenic, scalable, and osteogenic biofilm for in vivo osseointegration. Experimental and simulation studies showed vertical migration and horizontal juxtaposition of lactoferrin (LF) nanoaggregates at the air-water interface, forming 2D biofilms with highly controllable thickness, roughness, and adhesiveness. The inherent biocompatible, antibacterial, and osteogenic properties of LF clearly translated the biofilms into facile coatings for versatile surface biofunctionalization of various implants such as polylactic acid. Specifically, the defective tibiae in rat models receiving such implants featured a 149% increase in bone volume/tissue volume and a 57% increase in the number of bone trabeculae after an 8-week recovery, making the LF-based biofilms the best among the biomolecular osteo-regenerative coatings reported so far. This study provided a compelling example of how the inherent biofunctions of natural proteins can be combined with surface biofunctionalization towards advanced biomedical applications.
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