替莫唑胺
化学免疫疗法
黑色素瘤
癌症研究
透明质酸
药品
达卡巴嗪
材料科学
医学
免疫疗法
药理学
内科学
癌症
解剖
胶质母细胞瘤
作者
Yechun Jiang,Jiang Yu,Chengcheng Feng,Yayun Wu,Weinan Zhang,Xiao Liang,Zhaoyou Chu,Benjin Chen,Yan Ma,Haisheng Qian,Lei Xu
标识
DOI:10.1002/adhm.202303215
摘要
Topical therapy has received worldwide attention for in situ tumors owing to its higher efficacy of drug delivery. Herein, this work reports a dissolvable multifunctional hyaluronic acid microneedles (HMNs) patch coloaded with temozolomide (TMZ) and MnCl2 (TMZ/MnCl2 @HMN) for chemoimmunotherapy of melanoma. HMNs can ensure the stability of TMZ over time, and exhibit fewer side effects with a localized release way. In particular, TMZ not only promotes dendritic cell maturation by triggering immunogenic cell death in tumor cells, but also induces DNA damage that can further enhance the Mn2+ -activated cGAS-STING (stimulator of interferon genes pathway). As a result, the TMZ/MnCl2 @HMN multifunctional platform significantly inhibits lung metastases for melanoma, providing a practical strategy for precision therapy of melanoma.
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