化学
烷基化
烷基
甘氨酸
催化作用
光催化
氧化磷酸化
有机化学
药物化学
组合化学
氨基酸
光催化
生物化学
作者
Hari Babu Madala,Eunbin Jang,Hyesu Jang,Sang Kyum Kim,Jaehoon Sim
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2024-03-11
摘要
Herein, oxidative α-C(sp3)-H alkylation of N-arylated glycine derivatives with 4-alkyl dihydropyridine derivatives (alkyl-DHPs) as versatile alkyl radical precursors has been developed. Utilizing visible light-driven photoredox catalysis and ammonium persulfate as an oxidizing agent, this methodology facilitates the site-selective alkylation of glycine derivatives, enabling the site selective alkylation of peptides. The reaction exhibits broad substrate scope, including various alkyl radicals and acid-labile functional groups. This approach expands the synthetic toolbox in peptide chemistry, offering a mild and efficient method for the synthesis of modified peptides.
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