A new sacculatane diterpenoid and a new oplopanone sesquiterpenoid from Porella perrottetiana (Mont.) Trevis. collected in Sapa, Vietnam

From the n-hexane extract of the liverwort Porella perrottetiana collected in Sapa (North Vietnam), a new sacculatane diterpenoid (perrottetianal E (1)) and a new oplopanone sesquiterpenoid ((+)-oplopanone C (2)), along with two known sesquiterpenes (3 and 4), and two known phaeophytins (5 and 6) have been isolated. Their structures were elucidated based on the analysis of NMR spectroscopic data, in combination with HR-ESIMS and the reported data. Compounds 1-4 were evaluated for their cytotoxic activities against three cancer cell lines: KB (human carcinoma in the mouth), HepG2 (human hepatocellular carcinoma), and A549 (human lung carcinoma).