医学
生长激素
内分泌学
内科学
长寿
安慰剂
生长激素缺乏
激素
老年学
病理
替代医学
作者
Camille Hage,Roberto Salvatori
标识
DOI:10.1016/j.ecl.2022.10.003
摘要
Growth hormone (GH) secretion declines with aging (somatopause). One of the most controversial issues in aging is GH treatment of older adults without evidence of pituitary pathology. Although some clinicians have proposed reversing the GH decline in the older population, most information comes from not placebo-controlled studies. Although most animal studies reported an association between decreased GH levels (or GH resistance) and increased lifespan, human models have shown contradictory reports on the consequences of GH deficiency (GHD) on longevity. Currently, GH treatment in adults is only indicated for individuals with childhood-onset GHD transitioning to adulthood or new-onset GHD due to hypothalamic or pituitary pathologic processes.
科研通智能强力驱动
Strongly Powered by AbleSci AI