赖氨酸
染色质
乙酰化
酶
生物化学
化学
乙酰转移酶
染色质重塑
细胞生物学
转录因子
生物
基因
氨基酸
作者
Doudou Tan,Wei Wei,Zhigang Han,Xuelian Ren,Cong Yan,Shankang Qi,Xiaohan Song,Y. George Zheng,Jiemin Wong,He Huang
出处
期刊:iScience
[Elsevier]
日期:2022-11-01
卷期号:25 (11): 105443-105443
被引量:5
标识
DOI:10.1016/j.isci.2022.105443
摘要
Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely unknown, hindering further functional studies. Here we identified and validated the lysine acetyltransferase (KAT) HBO1 as a "writer" of Kbz in mammalian cells. In addition, we report the benzoylome in mammalian cells, identifying 1747 Kbz sites; among them at least 77 are the HBO1-targeted Kbz substrates. Bioinformatics analysis showed that HBO1-targeted Kbz sites were involved in multiple processes, including chromatin remodeling, transcription regulation, immune regulation, and tumor growth. Our results thus identify the regulatory elements of the Kbz pathway and reveal the non-canonical enzymatic activity and functions of HBO1 in cellular physiology.
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