SYNTHESIS AND EVALUATION OF XANTHINE-BASED COMPOUNDS AS ANTI-OBESITY AGENTS

The work was carried out with an object to synthesize xanthine products and assess the anti-obesity action of the synthesized compounds. The conjugates were yellow to brown in color and obtained in 68-71 % yields and were slightly soluble in water, insoluble in methanol and DMSO while they were soluble in chloroform. The confirmation of the structures of the compounds was done by 1H-NMR, mass, and IR spectral study. SAO1-5 were found to be hypophagic and restrict the intake of food by the mice and the hyperphagic effect of (±) - 8- OH-DPAT was antagonized by SAO.