后代
环境卫生
怀孕
医学
肥胖
代谢综合征
疾病
人口
糖尿病
脂肪肝
流行病学
生物
内分泌学
病理
遗传学
作者
Jun Sun,Haoyin Liu,Cong Zhang,Xiaofang Liu,Xiance Sun,Xin Chen,Guang Yang,Ningning Wang
出处
期刊:Life Sciences
[Elsevier]
日期:2022-12-01
卷期号:310: 121054-121054
被引量:9
标识
DOI:10.1016/j.lfs.2022.121054
摘要
Ambient air pollution is one of the most serious public health problems over the last decade. It causes about 4.2 million deaths worldwide each year, and fine particulate matter (PM2.5) is one of the major components of air pollution. Many chronic non-communicable diseases may originate from the early-life environment that alters the development of offspring. Pregnancy and lactation are plastic “window periods” for offspring metabolism, during which PM2.5 exposure is associated with long-term metabolic dysfunction in offspring. In this review, we summarized the scientific evidence from both epidemiological and toxicological studies, which suggest that perinatal exposure to PM2.5 causes obesity and metabolic diseases in progeny, including hypertension, cardiometabolic dysfunction, diabetes, and non-alcoholic fatty liver disease (NAFLD). Therefore, prevention strategies are needed to inform government policies and clinical counseling to reduce maternal exposure and its associated health hazards, and ultimately improve the quality of the newborn population.
科研通智能强力驱动
Strongly Powered by AbleSci AI