精子发生
内科学
促性腺激素
内分泌学
生物
斑马鱼
睾酮(贴片)
氟他胺
旁分泌信号
促性腺激素释放激素
自分泌信号
促黄体激素
雄激素
激素
雄激素受体
受体
医学
遗传学
癌症
基因
前列腺癌
作者
Hamideh P. Fallah,Aldo Tovo-Neto,Edward C. Yeung,Rafael Henrique Nóbrega,Hamid R. Habibi
标识
DOI:10.1016/j.mce.2019.04.020
摘要
Control of testicular development is multifactorial and involves a number of hypothalamic, hypophyseal and peripheral hormones. Here, we investigated direct action of zebrafish gonadotropin-inhibitory hormone (zGnih) which is expressed in the testis, on spermatogenesis in zebrafish, in vitro. Treatment with zGnih at the lower doses (10 and 100 nM) inhibited gonadotropin-induced spermatids/spermatozoa (SPD/SPZ) production. However, at the highest dose (1000 nM), zGnih increased basal number of SPD/SPZ and showed paradoxical effect. The effects of zGnih on testosterone and SPD/SPZ production was blocked in the presence of androgen receptor antagonist, flutamide (FLU). A number of transcripts were also measured to better understand zGnih mechanisms of action on zebrafish spermatogenesis. Our results provide strong support for the hypothesis that locally produced zGnih is a component of the complex multifactorial system that regulates testicular development and function in adult zebrafish, in part, by changes in testicular steroidogenesis and regulation of gonadotropin-induced response.
科研通智能强力驱动
Strongly Powered by AbleSci AI