白藜芦醇
氧化应激
丙烯酰胺
生物钟
昼夜节律
化学
线粒体
隐色素
细胞凋亡
药理学
炎症
生物
生物化学
内分泌学
免疫学
有机化学
聚合物
共聚物
作者
Xiao Di Tan,Ling Li,Wang Jia,Beita Zhao,Junru Pan,Leran Wang,Xiao Liu,Xuebo Liu,Zhigang Liu
标识
DOI:10.1021/acs.jafc.9b03368
摘要
Acrylamide, mainly formed in Maillard browning reaction during food processing, causes defects in liver circadian clock and mitochondrial function by inducing oxidative stress. Resveratrol is a polyphenol that has powerful antioxidant and anti-inflammatory activity. However, the preventive effects of resveratrol on acrylamide-triggered oxidative damage and circadian rhythm disorders are unclear at the current stage. The present research revealed that resveratrol pretreatment prevented acrylamide-induced cell death, mitochondrial dysfunction, and inflammatory responses in HepG2 liver cells. Acrylamide significantly triggered disorders of circadian genes transcription and protein expressions including Bmal1 and Cry 1 in primary hepatocytes, which were prevented by resveratrol pretreatment. Moreover, we found that the beneficial effects of resveratrol on stimulating Nrf2/NQO-1 pathway and mitochondrial respiration complex expressions in acrylamide-treated cells were Bmal1-dependent. Similarly, the inhibitory effects of resveratrol on inflammation signaling NF-κB were Cry1-dependent. In conclusion, these results demonstrated resveratrol could be a promising compound in suppressing acrylamide-induced hepatotoxicity and balancing the circadian clock.
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