Discovery of Biphenyl-Based Keap1–Nrf2 PPI Inhibitors through Scaffold Hopping Strategy: SAR Optimization, Biological Evaluation, and In Vivo Validation

Acute lung injury (ALI) is a life-threatening inflammatory disease associated with excessive oxidative stress and uncontrolled inflammatory responses. Although activation of the Keap1-Nrf2 pathway represents a promising therapeutic strategy, the...