脂肪肝
甘油三酯
化学
生物化学
脂肪酸
谷蛋白
胆汁酸
高脂血症
胆酸
胆固醇
代谢组学
肝病
多不饱和脂肪酸
脂肪酶
鹅去氧胆酸
脂质代谢
生物
代谢途径
内科学
代谢综合征
肝损伤
白蛋白
内分泌学
作者
Mingxi Li,Hongyan Li,Jia Zou,R. M. J. Li,Haoqi Zhang,Wenhan Yang,Xiaowei Wu,Chongzhen Sun
出处
期刊:Food & Function
[Royal Society of Chemistry]
日期:2025-12-23
卷期号:17 (2): 819-832
摘要
< 0.05). Serum biochemical analyses showed improvements in ALT, AST, lipid profiles, and lipopolysaccharide levels, accompanied by decreased expression of inflammatory cytokines (IL-6, IL-1β, TNF-α) and suppression of the TLR4/MyD88/NF-κB signaling pathway. Furthermore, untargeted serum metabolomics revealed that UDG markedly regulated metabolic profiles, with enrichment in pathways related to bile acid metabolism, amino acid metabolism, and central carbon metabolism. Notably, metabolites such as cholic acid and chenodeoxycholic acid were negatively correlated with NAFLD indicators and restored by UDG intervention. These findings show that UDG exerts lipid-lowering, hepatoprotective, and anti-inflammatory effects against NAFLD, potentially through modulation of bile acid biosynthesis and serum metabolic pathways. This study highlights mulberry leaf glutelin as a promising plant protein source with functional food potential for NAFLD prevention and management.
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